In TN., and North Ga. right now, the best patterns are:
Dry Flies: Gray Midge 18-22
Blue Quill 18-22
Male Adams 12-16
Royal Wulf 12-16
Griffith Gnat 18-22
RS2 Emerger 18-22
Nympths: Blue Wing Olive 12-18
Pheasant-Tail Bead-Head 12-20
Hare's Ear Bead-Head 10-18
Helgramite patterns, woolly-buggers, muddler minnows, Clousers and Black-nosed Daces always work around here, year-around.