I tend to think the best knots are those that I can consistently tie well, so I tend to stick with the knots and system that I have experience with.

I use a whipped loop in the end of my fly line, a perfection loop in my leader butt and loop-to-loop connection of leader to line. Blood knots in the butt and taper section of leaders. Triple surgeons' knot or tippet ring with improved clinch knots in the tippet sections. Improved clinch knot to attach flies to tippet.

I don't use overhand knots (except for the occassional accidentaly knot). However, I've heard they are not as bad / weak as we sometimes think.

There's some good, objective info at https://www.yellowstoneangler.com/ge...r-stoft-umpqua.