One notion that has not been addressed directly is 'structure', particularly the intersection of more than one structure. In other words, 'where is the most interesting place on the lake?' As mentioned, the inlet would be one, same with the outlet. A cliff face (with presumably either a steep drop underwater or fallen rocks or both), a fallen tree or collection of driftwood, weeds and lily pads - or better yet, reeds and lilies near an inlet with fallen trees nearby! The more interesting the location, the more chances for prey to grow (and more kinds of prey), and the more places for fish to ambush, hide, rest.
If the lake is 100 acres then I'd say the belly boat is out, but most other craft would work. I'm another that would start with a WB about 4ft deep. If I had good action I might try near/top water with and emerger or wet fly, but if I had no action I would go deeper and slower with a dragonfly nymph.