I usually fish 3 flies with heaviest to the leader tippet. Each successive fly is tied to an x size smaller tippet and tied to bend of the previous fly. In the spring we often have caddis and mayflies emerging at the same time so i will use two appropriate color and sizes of soft hackles behind the weight fly. In the winter I will almost always have a midge pupa or two in the mix. The weight fly varies by area & season caddis larvae ,crane fly larvae , general attractor, tungsten egg, marabou jig.
Make sure you leader is well tapered and use roll casts or water load casts