Are there any well known fish catching nymphs that you can't catch a fish on no matter how much you try?

My example is the Skip Nymph. It makes sense to me with the dark back and lighter belly. I have confidence in it when I tie it on because it looks so good. I just can't catch anything with it or its different colors or variations. I'll go back over the same water with a traditional Hare's Ear or PT in the same size and weight and be successful.

Do you have any nymphs like this?