I fish them throughout the water column with weight, heavy hooks whatever it takes. Also I fish them when there is no hatch, all winter lond. At times I will drop a s/h off the back of a big nymph to get it down. As far as fishing methods I'll vary the presentation as to the water flow, depth, etc. But it is usually up and across to give the fly a chance to get where the fish my be holding. I will also use a sinking leader such as Orvis, RIO, or AirFlo sell. To this I attach about a three foot section of tippet, usually 5X