I fished that area solo extensively the summer that I worked in the park. Just take bear spray, don't sneak up on anything, basically all the usual precautions. I second the Chernobyl ant recommendation. Madam X, Convertibles, your hopper of choice paired with a dropper (prince, hare's ear) will all produce. You can effectively sight cast in slough creek. My advice is to get up early and hike in to the second meadow (about 3-4 miles if I remember correct). Bring plenty of water and snacks and stay there the whole day; there is plenty of water to explore.