After Dshocks thread concerning SpyWare I thought it would be interesting to see how others setup their home computers. For Me:

Browser - Mozilla FireFox with the FireFTP and Foxytunes extension
E-mail - Mozilla Thunderbird with Sunbird/Lightening extension for my calendar.
Business - OpenOffice for Word Processing, Spreadsheet, Presentations, Database,etc.
Accounting - Quicken
Music - iTunes
Firewall - SpySweeper
Anti-Virus - SpySweeper
Anti-Spyware - SpySweeper

I find these to be the essentials for Home needs. Most are "open source" and free downloads keeps the expenses down (More for FF toys ). I have heard good things about other products as well like: AVG Anti-Virus, Safari, etc. What do you use and why do you find it better? I tried Safari and did find it superior to FireFox except the beta version was quite buggy and blew me out of the browser on several sites.