I have never personally tried either one, but from what I have heard and read online and observed from driving by, the Eno is definately wadeable. It is a fairly rocky stream, small, with a fair population of sunfish. Not unlike a small trout stream, but filled with better fish The Neuse is deeper, murkier and dirtier, and potentially dangerous unless you have some local knowledge--I would definately stick with the Eno. I have meant to fish there, but I live in Greensboro and there is too much water around here.