At 6' 3" with rather large hands I ended up with a few rods that I 'knew' the grips would be too narrow on. I was wrong.
Since using them for a couple years, large grips seem to wear my hand out. In fact, I used to get a callus on my pinky large knuckle. The only time it appears now is when I'm playing the salt with higher line weight rods for a few days. I vote for large grips only on line weights 7 and above.